| 1. Round | 04/02/2022 | Club Olimpia | - | General Caballero DJLM | 2:2 | ||||
| 5. Round | 06/03/2022 | Club Olimpia | - | Tacuary | 2:0 | ||||
| 8. Round | 02/04/2022 | Resistencia SC | - | Club Olimpia | 2:1 | ||||
| 9. Round | 09/04/2022 | Club Olimpia | - | Club Nacional | 1:2 |  |
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| 10. Round | 16/04/2022 | 12 de Octubre de Itauguá | - | Club Olimpia | 0:0 | ||||
| 11. Round | 20/04/2022 | Club Olimpia | - | Guaraní | 1:0 | ||||
| 12. Round | 24/04/2022 | General Caballero DJLM | - | Club Olimpia | 2:3 | |
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| 13. Round | 02/05/2022 | Club Olimpia | - | Guaireña FC | 1:0 | |
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| 14. Round | 08/05/2022 | Libertad | - | Club Olimpia | 1:0 | ||||
| 15. Round | 11/05/2022 | Club Olimpia | - | Sol de América | 1:0 | |
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| 16. Round | 16/05/2022 | Tacuary | - | Club Olimpia | 1:4 | |
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| 18. Round | 14/06/2022 | Sportivo Ameliano | - | Club Olimpia | 1:4 | ||||
| 20. Round | 23/06/2022 | Club Nacional | - | Club Olimpia | 1:1 | ||||
| 21. Round | 26/06/2022 | Club Olimpia | - | 12 de Octubre de Itauguá | 4:1 | |
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| 22. Round | 03/07/2022 | Guaraní | - | Club Olimpia | 0:2 | |
Paraguay