1. Round | 04/02/2022 | Club Olimpia | - | General Caballero DJLM | 2:2 | ||||
5. Round | 06/03/2022 | Club Olimpia | - | Tacuary | 2:0 | ||||
8. Round | 02/04/2022 | Resistencia SC | - | Club Olimpia | 2:1 | ||||
9. Round | 09/04/2022 | Club Olimpia | - | Club Nacional | 1:2 | ||||
10. Round | 16/04/2022 | 12 de Octubre de Itauguá | - | Club Olimpia | 0:0 | ||||
11. Round | 20/04/2022 | Club Olimpia | - | Guaraní | 1:0 | ||||
12. Round | 24/04/2022 | General Caballero DJLM | - | Club Olimpia | 2:3 | ||||
13. Round | 02/05/2022 | Club Olimpia | - | Guaireña FC | 1:0 | ||||
14. Round | 08/05/2022 | Libertad | - | Club Olimpia | 1:0 | ||||
15. Round | 11/05/2022 | Club Olimpia | - | Sol de América | 1:0 | ||||
16. Round | 16/05/2022 | Tacuary | - | Club Olimpia | 1:4 | ||||
18. Round | 14/06/2022 | Sportivo Ameliano | - | Club Olimpia | 1:4 | ||||
20. Round | 23/06/2022 | Club Nacional | - | Club Olimpia | 1:1 | ||||
21. Round | 26/06/2022 | Club Olimpia | - | 12 de Octubre de Itauguá | 4:1 | ||||
22. Round | 03/07/2022 | Guaraní | - | Club Olimpia | 0:2 |