| 1. Round | 19/01/2008 | Cruz Azul | - | Santos Laguna | 1:1 | ||||
| 4. Round | 10/02/2008 | Santos Laguna | - | CF Pachuca | 2:1 | ||||
| 5. Round | 14/02/2008 | Deportivo Guadalajara | - | Santos Laguna | 3:2 | ||||
| 8. Round | 02/03/2008 | Santos Laguna | - | CF Monterrey | 2:0 | ||||
| 9. Round | 09/03/2008 | Puebla FC | - | Santos Laguna | 3:3 | ||||
| 10. Round | 16/03/2008 | Santos Laguna | - | Jaguares Chiapas | 1:3 | ||||
| 11. Round | 23/03/2008 | Pumas UNAM | - | Santos Laguna | 1:1 | ||||
| 12. Round | 30/03/2008 | Santos Laguna | - | UAG Tecos | 4:0 | ||||
| 13. Round | 06/04/2008 | Monarcas Morelia | - | Santos Laguna | 0:0 | ||||
| 14. Round | 13/04/2008 | Santos Laguna | - | Atlas Guadalajara | 6:1 | ||||
| 15. Round | 20/04/2008 | Santos Laguna | - | Club Necaxa | 1:1 |  |
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| 16. Round | 27/04/2008 | UANL Tigres | - | Santos Laguna | 1:2 | |
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| 17. Round | 04/05/2008 | Santos Laguna | - | Club San Luis | 4:1 |
Argentina