| 1. Round | 11/02/2005 | Olimpo de Bahía Blanca | - | San Lorenzo | 3:0 | ||||
| 3. Round | 27/02/2005 | Gimnasia de La Plata | - | San Lorenzo | 3:1 | ||||
| 4. Round | 06/03/2005 | San Lorenzo | - | Independiente | 2:4 |  |
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| 5. Round | 13/03/2005 | Vélez Sarsfield | - | San Lorenzo | 2:0 | ||||
| 6. Round | 19/03/2005 | San Lorenzo | - | Rosario Central | 1:3 | ||||
| 8. Round | 10/04/2005 | San Lorenzo | - | Colón de Santa Fe | 0:0 | ||||
| 9. Round | 17/04/2005 | Banfield | - | San Lorenzo | 1:0 | ||||
| 11. Round | 30/04/2005 | Instituto de Córdoba | - | San Lorenzo | 1:1 | ||||
| 12. Round | 08/05/2005 | San Lorenzo | - | River Plate | 3:1 | ||||
| 15. Round | 28/05/2005 | Newell's Old Boys | - | San Lorenzo | 1:1 | ||||
| 16. Round | 11/06/2005 | San Lorenzo | - | Quilmes | 2:0 | ||||
| 17. Round | 18/06/2005 | Almagro | - | San Lorenzo | 3:1 | ||||
| 18. Round | 26/06/2005 | San Lorenzo | - | Lanús | 3:1 | ||||
| 19. Round | 03/07/2005 | Racing Club | - | San Lorenzo | 0:1 |
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