| 7. Round | 09/11/2020 | Mazorqueros | - | Atlético San Luis II | 1:0 | ||||
| 8. Round | 14/11/2020 | Atlético San Luis II | - | Colima FC | 2:0 | ||||
| 9. Round | 23/11/2020 | Atlético San Luis II | - | Reboceros de La Piedad | 0:2 | ||||
| 10. Round | 06/12/2020 | Gavilanes de Matamoros | - | Atlético San Luis II | 1:0 |  |
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| 11. Round | 13/12/2020 | Atlético San Luis II | - | Tuzos de la UAZ | 1:1 | |
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| 12. Round | 16/01/2021 | Atlético San Luis II | - | Alacranes de Durango | 1:1 | ||||
| 13. Round | 25/01/2021 | Cimarrones de Sonora II | - | Atlético San Luis II | 0:2 | ||||
| 14. Round | 29/01/2021 | Atlético San Luis II | - | Saltillo FC | 2:0 | ||||
| 15. Round | 07/02/2021 | Leones Negros II | - | Atlético San Luis II | 1:2 | ||||
| 16. Round | 13/02/2021 | Atlético San Luis II | - | Tecos Fútbol Club | 1:2 | |
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| 17. Round | 20/02/2021 | Mineros de Fresnillo FC | - | Atlético San Luis II | 1:2 | ||||
| 19. Round | 14/03/2021 | Colima FC | - | Atlético San Luis II | 2:0 |
Mexico