| 1. Round | 20/07/2019 | Puebla FC | - | Club Tijuana | 1:3 |  |
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| 2. Round | 28/07/2019 | Club Tijuana | - | Gallos Blancos | 1:1 | |
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| 3. Round | 04/08/2019 | CF América | - | Club Tijuana | 3:1 | ||||
| 4. Round | 10/08/2019 | Club Tijuana | - | Pumas UNAM | 1:0 | ||||
| 6. Round | 25/08/2019 | Deportivo Toluca | - | Club Tijuana | 2:0 | ||||
| 7. Round | 29/08/2019 | Club Tijuana | - | Cruz Azul | 3:2 | ||||
| 10. Round | 22/09/2019 | CF Pachuca | - | Club Tijuana | 4:1 | ||||
| 11. Round | 26/09/2019 | Club Tijuana | - | Monarcas Morelia | 3:2 | ||||
| 12. Round | 29/09/2019 | Atlético San Luis | - | Club Tijuana | 2:3 | ||||
| 16. Round | 31/10/2019 | Deportivo Guadalajara | - | Club Tijuana | 0:1 | ||||
| 18. Round | 09/11/2019 | Club Tijuana | - | CF Monterrey | 0:4 |
Uruguay