| 4. Round | 30/08/2015 | Vitesse | - | SC Cambuur | 4:1 | ||||
| 5. Round | 12/09/2015 | SC Cambuur | - | PSV Eindhoven | 0:6 |  |
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| 6. Round | 19/09/2015 | SC Cambuur | - | FC Twente | 0:0 | ||||
| 7. Round | 26/09/2015 | FC Utrecht | - | SC Cambuur | 3:3 | ||||
| 8. Round | 03/10/2015 | Roda JC Kerkrade | - | SC Cambuur | 1:1 | ||||
| 9. Round | 17/10/2015 | SC Cambuur | - | AZ Alkmaar | 1:1 |  |
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| 11. Round | 01/11/2015 | sc Heerenveen | - | SC Cambuur | 2:0 | ||||
| 12. Round | 08/11/2015 | SC Cambuur | - | FC Groningen | 2:2 | |
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| 13. Round | 21/11/2015 | AFC Ajax | - | SC Cambuur | 5:1 | ||||
| 14. Round | 27/11/2015 | SC Cambuur | - | De Graafschap | 2:3 | ||||
| 16. Round | 12/12/2015 | SC Cambuur | - | NEC Nijmegen | 3:1 | ||||
| 17. Round | 20/12/2015 | SBV Excelsior | - | SC Cambuur | 1:4 | ||||
| 18. Round | 16/01/2016 | SC Cambuur | - | Vitesse | 0:2 | ||||
| 20. Round | 27/01/2016 | AZ Alkmaar | - | SC Cambuur | 3:1 | ||||
| 22. Round | 07/02/2016 | FC Groningen | - | SC Cambuur | 2:0 | ||||
| 23. Round | 12/02/2016 | SC Cambuur | - | FC Utrecht | 0:2 | ||||
| 24. Round | 20/02/2016 | FC Twente | - | SC Cambuur | 3:0 | ||||
| 26. Round | 06/03/2016 | Feyenoord | - | SC Cambuur | 3:1 | ||||
| 34. Round | 08/05/2016 | SC Cambuur | - | SBV Excelsior | 0:2 |
Netherlands