| 1. Round | 11/03/2021 | Club Aurora | - | Royal Pari | 0:8 | ||||
| 2. Round | 15/03/2021 | Royal Pari | - | Real Tomayapo | 4:2 | ||||
| 3. Round | 03/04/2021 | Club San José | - | Royal Pari | 0:3 | ||||
| 4. Round | 09/04/2021 | Royal Pari | - | Real Santa Cruz | 3:2 |  |
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| 5. Round | 24/04/2021 | Nacional Potosí | - | Royal Pari | 2:1 | ||||
| 8. Round | 10/07/2021 | Royal Pari | - | Jorge Wilstermann | 3:2 | |
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| 9. Round | 17/07/2021 | Atlético Palmaflor | - | Royal Pari | 2:0 | ||||
| 10. Round | 21/07/2021 | Royal Pari | - | Always Ready | 2:1 | ||||
| 11. Round | 25/07/2021 | Independiente Petrolero | - | Royal Pari | 1:0 | ||||
| 16. Round | 19/08/2021 | Royal Pari | - | Club Aurora | 1:0 | ||||
| 21. Round | 28/09/2021 | Oriente Petrolero | - | Royal Pari | 2:4 |  |
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| 22. Round | 19/10/2021 | Royal Pari | - | The Strongest | 0:1 | |
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| 24. Round | 28/10/2021 | Royal Pari | - | Atlético Palmaflor | 2:2 | ||||
| 25. Round | 31/10/2021 | Always Ready | - | Royal Pari | 2:1 | ||||
| 30. Round | 10/12/2021 | Bolívar | - | Royal Pari | 2:0 |
Bolivia