| 1. Round | 22/07/2018 | Sport Boys Warnes | - | Destroyers | 3:0 | ||||
| 2. Round | 25/07/2018 | Nacional Potosí | - | Destroyers | 0:0 | ||||
| 3. Round | 30/07/2018 | Destroyers | - | Blooming | 1:1 | ||||
| 4. Round | 02/08/2018 | The Strongest | - | Destroyers | 4:1 | ||||
| 5. Round | 04/08/2018 | Destroyers | - | Jorge Wilstermann | 0:0 | ||||
| 6. Round | 12/08/2018 | CD Guabirá | - | Destroyers | 3:2 | ||||
| 7. Round | 19/08/2018 | Destroyers | - | Club San José | 3:0 | ||||
| 8. Round | 25/08/2018 | Destroyers | - | Real Potosí | 2:1 | ||||
| 10. Round | 15/09/2018 | Bolívar | - | Destroyers | 5:1 | ||||
| 21. Round | 14/10/2018 | Club San José | - | Destroyers | 3:1 |  |
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| 16. Round | 25/10/2018 | Destroyers | - | Nacional Potosí | 0:2 | ||||
| 17. Round | 28/10/2018 | Destroyers | - | The Strongest | 0:1 | ||||
| 18. Round | 04/11/2018 | Jorge Wilstermann | - | Destroyers | 2:1 | |
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| 19. Round | 10/11/2018 | Destroyers | - | CD Guabirá | 1:2 | ||||
| 20. Round | 24/11/2018 | Real Potosí | - | Destroyers | 3:2 |
Bolivia