| 5. Round | 05/03/2022 | Resistencia SC | - | Guaireña FC | 2:2 | ||||
| 6. Round | 12/03/2022 | Sol de América | - | Resistencia SC | 1:1 |  |
|||
| 8. Round | 02/04/2022 | Resistencia SC | - | Club Olimpia | 2:1 | ||||
| 9. Round | 08/04/2022 | 12 de Octubre de Itauguá | - | Resistencia SC | 1:1 | |
|||
| 10. Round | 18/04/2022 | Resistencia SC | - | General Caballero DJLM | 2:1 | |
|||
| 11. Round | 21/04/2022 | Libertad | - | Resistencia SC | 2:2 | |
|||
| 12. Round | 25/04/2022 | Tacuary | - | Resistencia SC | 3:1 | |
|||
| 16. Round | 14/05/2022 | Guaireña FC | - | Resistencia SC | 0:0 | |
|||
| 17. Round | 21/05/2022 | Resistencia SC | - | Sol de América | 0:0 | ||||
| 18. Round | 15/06/2022 | Cerro Porteño | - | Resistencia SC | 1:0 | ||||
| 19. Round | 19/06/2022 | Club Olimpia | - | Resistencia SC | 6:1 | ||||
| 20. Round | 22/06/2022 | Resistencia SC | - | 12 de Octubre de Itauguá | 0:1 | ||||
| 21. Round | 25/06/2022 | General Caballero DJLM | - | Resistencia SC | 2:1 | |
|||
| 22. Round | 03/07/2022 | Resistencia SC | - | Libertad | 0:4 |
Paraguay