| 1. Round | 17/07/2010 | Tacuary | - | Club Rubio Ñu | 0:0 | ||||
| 2. Round | 24/07/2010 | Club Rubio Ñu | - | Sport Colombia | 1:0 | ||||
| 3. Round | 30/07/2010 | Club Olimpia | - | Club Rubio Ñu | 1:4 |  |
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| 4. Round | 07/08/2010 | Libertad | - | Club Rubio Ñu | 2:1 | ||||
| 5. Round | 15/08/2010 | Club Rubio Ñu | - | 3 de Febrero | 1:1 | ||||
| 8. Round | 04/09/2010 | Club Nacional | - | Club Rubio Ñu | 0:0 | ||||
| 9. Round | 12/09/2010 | Club Rubio Ñu | - | Sol de América | 2:1 | ||||
| 10. Round | 19/09/2010 | Sportivo Trinidense | - | Club Rubio Ñu | 1:2 | ||||
| 11. Round | 27/09/2010 | Guaraní | - | Club Rubio Ñu | 1:2 | ||||
| 12. Round | 02/10/2010 | Club Rubio Ñu | - | Tacuary | 1:2 | ||||
| 13. Round | 10/10/2010 | Sport Colombia | - | Club Rubio Ñu | 2:0 | ||||
| 14. Round | 17/10/2010 | Club Rubio Ñu | - | Club Olimpia | 2:2 | ||||
| 15. Round | 20/10/2010 | Club Rubio Ñu | - | Libertad | 1:3 | ||||
| 18. Round | 06/11/2010 | Cerro Porteño | - | Club Rubio Ñu | 2:0 | ||||
| 19. Round | 12/11/2010 | Club Rubio Ñu | - | Club Nacional | 1:1 |
Paraguay