| 2. Round | 29/01/2016 | Sol de América | - | River Plate | 0:1 |  |
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| 3. Round | 03/02/2016 | River Plate | - | Sportivo Luqueño | 0:1 | ||||
| 4. Round | 08/02/2016 | Libertad | - | River Plate | 3:1 | ||||
| 5. Round | 13/02/2016 | River Plate | - | General Caballero ZC | 0:0 | ||||
| 6. Round | 20/02/2016 | Club Nacional | - | River Plate | 0:0 | ||||
| 13. Round | 06/04/2016 | River Plate | - | Sol de América | 1:1 | ||||
| 14. Round | 11/04/2016 | Sportivo Luqueño | - | River Plate | 2:0 | ||||
| 15. Round | 17/04/2016 | River Plate | - | Libertad | 1:3 | |
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| 16. Round | 21/04/2016 | General Caballero ZC | - | River Plate | 2:3 | ||||
| 17. Round | 25/04/2016 | River Plate | - | Club Nacional | 1:3 | ||||
| 18. Round | 30/04/2016 | Guaraní | - | River Plate | 4:2 | |
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| 19. Round | 06/05/2016 | River Plate | - | Deportivo Capiatá | 1:1 | ||||
| 20. Round | 08/05/2016 | Club Rubio Ñu | - | River Plate | 1:2 | |
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| 21. Round | 14/05/2016 | River Plate | - | General Díaz | 1:1 | |
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| 22. Round | 21/05/2016 | Club Olimpia | - | River Plate | 3:0 |
Paraguay