| 1. Round | 11/09/2021 | sc Heerenveen [Youth B] | - | NEC Nijmegen [Youth B] | 5:0 | ||||
| 2. Round | 15/09/2021 | NEC Nijmegen [Youth B] | - | AFC Ajax [Youth B] | 2:4 | ||||
| 5. Round | 02/10/2021 | AZ Alkmaar [Youth B] | - | NEC Nijmegen [Youth B] | 7:0 | ||||
| 6. Round | 16/10/2021 | PSV Eindhoven [Youth B] | - | NEC Nijmegen [Youth B] | 5:0 | ||||
| 7. Round | 23/10/2021 | NEC Nijmegen [Youth B] | - | FC Utrecht [Youth B] | 1:5 | ||||
| 9. Round | 06/11/2021 | Feyenoord [Youth B] | - | NEC Nijmegen [Youth B] | 2:3 | ||||
| 10. Round | 08/02/2022 | NEC Nijmegen [Youth B] | - | PEC Zwolle [Youth B] | 2:3 |
Netherlands