| Zona B | 03/03/2021 | CSD Municipal | - | Sanarate | 3:1 | ||||
| Zona B | 06/03/2021 | Cobán Imperial | - | Sanarate | 2:0 | ||||
| Zona B | 10/03/2021 | Sanarate | - | Achuapa | 2:1 | ||||
| Zona B | 14/03/2021 | Sanarate | - | Deportivo Guastatoya | 3:2 |  |
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| Interzone | 21/04/2021 | Sanarate | - | Iztapa | 1:1 | ||||
| Interzone | 24/04/2021 | Santa Lucía | - | Sanarate | 1:0 | ||||
| Interzone | 28/04/2021 | Sanarate | - | Xelaju MC | 1:1 | ||||
| Interzone | 02/05/2021 | Deportivo Malacateco | - | Sanarate | 0:1 | ||||
| Quarter-finals | 05/05/2021 | Sanarate | - | Deportivo Guastatoya | 2:0 |  |
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| Quarter-finals | 08/05/2021 | Deportivo Guastatoya | - | Sanarate | 4:1 |
Guatemala