1. Round | 16/07/2022 | Sportivo Ameliano | - | Libertad | 2:0 | ||||
2. Round | 20/07/2022 | Libertad | - | Club Olimpia | 4:2 | ||||
3. Round | 24/07/2022 | General Caballero DJLM | - | Libertad | 3:2 | ||||
11. Round | 14/09/2022 | Libertad | - | Tacuary | 2:0 | ||||
14. Round | 02/10/2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
16. Round | 09/10/2022 | Libertad | - | 12 de Octubre de Itauguá | 2:2 | ||||
17. Round | 17/10/2022 | Sol de América | - | Libertad | 1:1 | ||||
18. Round | 23/10/2022 | Libertad | - | Club Nacional | 0:1 | ||||
21. Round | 06/11/2022 | Libertad | - | Guaireña FC | 4:2 |