| 1. Round | 14/08/2021 | RWD Molenbeek | - | Royal Excel Mouscron | 3:1 | ||||
| 2. Round | 21/08/2021 | Royal Excel Mouscron | - | Lommel SK | 0:1 | ||||
| 6. Round | 26/09/2021 | Royal Excel Mouscron | - | KVC Westerlo | 1:2 |  |
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| 7. Round | 02/10/2021 | Lierse Kempenzonen | - | Royal Excel Mouscron | 2:2 | ||||
| 8. Round | 17/10/2021 | Lommel SK | - | Royal Excel Mouscron | 3:0 | |
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| 9. Round | 22/10/2021 | Royal Excel Mouscron | - | RWD Molenbeek | 1:1 | |
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| 11. Round | 06/11/2021 | Royal Excel Mouscron | - | SK Deinze | 2:0 | ||||
| 27. Round | 08/04/2022 | Royal Excel Mouscron | - | KVC Westerlo | 2:6 | ||||
| 28. Round | 17/04/2022 | Waasland-Beveren | - | Royal Excel Mouscron | 2:0 | |
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