| 1. Round | 02/07/2022 | Independiente Petrolero | - | Universitario de Vinto | 1:1 |  |
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| 2. Round | 05/07/2022 | Royal Pari | - | Independiente Petrolero | 3:2 | ||||
| 3. Round | 10/07/2022 | Independiente Petrolero | - | Blooming | 3:0 | ||||
| 5. Round | 25/07/2022 | Independiente Petrolero | - | Universitario de Sucre | 2:0 | ||||
| 6. Round | 30/07/2022 | Club Aurora | - | Independiente Petrolero | 1:0 | |
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| 7. Round | 02/08/2022 | Independiente Petrolero | - | Oriente Petrolero | 1:2 | |
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| 8. Round | 06/08/2022 | Independiente Petrolero | - | Jorge Wilstermann | 4:1 | ||||
| 11. Round | 20/08/2022 | Independiente Petrolero | - | Real Santa Cruz | 1:0 | ||||
| 17. Round | 11/09/2022 | Independiente Petrolero | - | Royal Pari | 3:0 |  |
Bolivia