| 1. Round | 10/01/2016 | Club León | - | Santos Laguna | 2:0 | ||||
| 2. Round | 16/01/2016 | CD Veracruz | - | Club León | 1:3 |  |
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| 3. Round | 24/01/2016 | Club León | - | Cruz Azul | 3:2 | ||||
| 4. Round | 31/01/2016 | UANL Tigres | - | Club León | 3:1 | ||||
| 5. Round | 07/02/2016 | Club León | - | Monarcas Morelia | 1:2 | ||||
| 6. Round | 14/02/2016 | Deportivo Guadalajara | - | Club León | 0:1 | ||||
| 7. Round | 21/02/2016 | Club León | - | Deportivo Toluca | 5:1 | ||||
| 8. Round | 28/02/2016 | Club León | - | Chiapas FC | 1:3 | ||||
| 9. Round | 05/03/2016 | Club Tijuana | - | Club León | 0:0 | ||||
| 10. Round | 13/03/2016 | Club León | - | Gallos Blancos | 2:0 | ||||
| 11. Round | 19/03/2016 | CF América | - | Club León | 2:1 | ||||
| 12. Round | 03/04/2016 | Club León | - | CF Monterrey | 1:2 | ||||
| 13. Round | 11/04/2016 | Pumas UNAM | - | Club León | 1:2 | ||||
| 14. Round | 17/04/2016 | Club León | - | Puebla FC | 4:1 | ||||
| 15. Round | 24/04/2016 | Atlas Guadalajara | - | Club León | 1:1 | ||||
| 16. Round | 01/05/2016 | Club León | - | CF Pachuca | 0:0 | ||||
| 17. Round | 08/05/2016 | Dorados de Sinaloa | - | Club León | 0:1 |
Mexico
