| 1. Round | 27/06/2022 | Pumas Tabasco | - | Cancún FC | 1:2 | ||||
| 2. Round | 08/07/2022 | Club Celaya | - | Pumas Tabasco | 2:1 | ||||
| 11. Round | 07/09/2022 | Correcaminos UAT | - | Pumas Tabasco | 1:0 | ||||
| 12. Round | 14/09/2022 | Pumas Tabasco | - | Leones Negros | 0:2 | ||||
| 13. Round | 22/09/2022 | Atlético La Paz | - | Pumas Tabasco | 6:1 | ||||
| 16. Round | 05/10/2022 | Pumas Tabasco | - | Dorados de Sinaloa | 0:3 |  |
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| 17. Round | 11/10/2022 | CF Monterrey II | - | Pumas Tabasco | 2:2 | |
Mexico