| 3. Round | 13/09/2009 | Defensor Sporting | - | Nacional | 0:3 |  |
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| 4. Round | 20/09/2009 | Central Español | - | Defensor Sporting | 0:4 | |
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| 5. Round | 27/09/2009 | Defensor Sporting | - | Fénix | 2:0 | |
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| 6. Round | 04/10/2009 | Rampla Juniors | - | Defensor Sporting | 1:3 | ||||
| 7. Round | 18/10/2009 | Defensor Sporting | - | Cerrito | 1:0 | ||||
| 8. Round | 22/10/2009 | Defensor Sporting | - | Cerro Largo | 0:0 | ||||
| 9. Round | 27/10/2009 | Tacuarembó | - | Defensor Sporting | 0:1 | |
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| 10. Round | 31/10/2009 | Peñarol | - | Defensor Sporting | 1:1 | ||||
| 11. Round | 07/11/2009 | Defensor Sporting | - | Racing | 1:1 | ||||
| 12. Round | 22/11/2009 | CA Cerro | - | Defensor Sporting | 1:4 | |
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| 14. Round | 09/12/2009 | Montevideo Wanderers | - | Defensor Sporting | 2:2 | |
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| 15. Round | 13/12/2009 | Defensor Sporting | - | Liverpool | 2:2 |
Uruguay
Italy