| 2. Round | 21/02/2022 | Deportes Temuco | - | Santiago Wanderers | 1:0 | ||||
| 5. Round | 16/03/2022 | Santiago Wanderers | - | Rangers | 1:3 | ||||
| 12. Round | 01/05/2022 | Recoleta | - | Santiago Wanderers | 1:2 | ||||
| 13. Round | 06/05/2022 | Santiago Wanderers | - | Barnechea | 1:3 | ||||
| 14. Round | 13/05/2022 | Cobreloa | - | Santiago Wanderers | 1:1 | ||||
| 15. Round | 16/05/2022 | Santiago Wanderers | - | Universidad de Concepción | 0:0 | ||||
| 28. Round | 10/09/2022 | Unión San Felipe | - | Santiago Wanderers | 2:3 | ||||
| 29. Round | 25/09/2022 | Santiago Wanderers | - | Recoleta | 0:0 | ||||
| 34. Round | 02/11/2022 | Santiago Wanderers | - | Santa Cruz | 2:0 |
Brazil