| 1. Round | 01/07/2022 | Real Santa Cruz | - | Universitario de Sucre | 3:0 | ||||
| 2. Round | 07/07/2022 | Blooming | - | Real Santa Cruz | 5:1 |  |
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| 4. Round | 16/07/2022 | Real Tomayapo | - | Real Santa Cruz | 1:2 | ||||
| 6. Round | 26/07/2022 | Nacional Potosí | - | Real Santa Cruz | 3:1 | ||||
| 7. Round | 01/08/2022 | Real Santa Cruz | - | Club Aurora | 1:1 | ||||
| 11. Round | 20/08/2022 | Independiente Petrolero | - | Real Santa Cruz | 1:0 | ||||
| 14. Round | 01/09/2022 | Real Santa Cruz | - | Jorge Wilstermann | 0:0 | ||||
| 16. Round | 07/09/2022 | Universitario de Sucre | - | Real Santa Cruz | 3:1 | ||||
| 19. Round | 30/09/2022 | Real Santa Cruz | - | Real Tomayapo | 1:1 | |
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| 20. Round | 06/10/2022 | Oriente Petrolero | - | Real Santa Cruz | 3:1 | |
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| 21. Round | 08/10/2022 | Real Santa Cruz | - | Nacional Potosí | 2:1 | |
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| 22. Round | 13/10/2022 | Club Aurora | - | Real Santa Cruz | 1:2 | |
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| 24. Round | 19/10/2022 | The Strongest | - | Real Santa Cruz | 5:2 | |
Dom. Republic