| 4. Round | 05/06/2018 | Real Monarchs SLC | - | Rio Grande Valley FC | 2:0 | ||||
| 5. Round | 08/07/2018 | Rio Grande Valley FC | - | Tulsa Roughnecks | 1:1 | ||||
| 5. Round | 22/07/2018 | Swope Park Rangers | - | Rio Grande Valley FC | 0:0 | ||||
| 5. Round | 29/07/2018 | Rio Grande Valley FC | - | Colorado Springs Switchbacks | 1:0 | ||||
| 6. Round | 05/08/2018 | Las Vegas Lights FC | - | Rio Grande Valley FC | 1:0 | ||||
| 6. Round | 23/08/2018 | Los Angeles Galaxy II | - | Rio Grande Valley FC | 1:1 | ||||
| 6. Round | 30/08/2018 | Rio Grande Valley FC | - | San Antonio FC | 1:3 | ||||
| 7. Round | 16/09/2018 | Colorado Springs Switchbacks | - | Rio Grande Valley FC | 1:1 | ||||
| 7. Round | 23/09/2018 | Rio Grande Valley FC | - | Seattle Sounders 2 | 3:0 | ||||
| 7. Round | 30/09/2018 | Rio Grande Valley FC | - | Fresno FC | 2:1 | ||||
| 8. Round | 07/10/2018 | Tulsa Roughnecks | - | Rio Grande Valley FC | 1:2 | ||||
| 8. Round | 14/10/2018 | San Antonio FC | - | Rio Grande Valley FC | 1:1 |
USA
Colombia