| 4. Round | 03/08/2019 | River Plate | - | Club Nacional | 0:1 |  |
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| 9. Round | 13/09/2019 | River Plate | - | Deportivo Santaní | 1:0 | ||||
| 11. Round | 24/09/2019 | River Plate | - | San Lorenzo | 0:0 | ||||
| 14. Round | 20/10/2019 | River Plate | - | Club Olimpia | 0:1 | ||||
| 18. Round | 12/11/2019 | Sportivo Luqueño | - | River Plate | 1:2 | |
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| 17. Round | 23/11/2019 | River Plate | - | Libertad | 0:2 |
Paraguay