| 2. Round | 09/02/2021 | Club Nacional | - | Sol de América | 1:0 |  |
|||
| 4. Round | 21/02/2021 | Club Nacional | - | Libertad | 0:3 | ||||
| 5. Round | 01/03/2021 | Guaireña FC | - | Club Nacional | 1:0 | ||||
| 6. Round | 06/03/2021 | Club Nacional | - | Cerro Porteño | 2:0 | ||||
| 7. Round | 10/03/2021 | Club Olimpia | - | Club Nacional | 1:4 | ||||
| 8. Round | 13/03/2021 | River Plate | - | Club Nacional | 0:0 | |
|||
| 11. Round | 10/04/2021 | Sol de América | - | Club Nacional | 1:2 | ||||
| 12. Round | 17/04/2021 | Club Nacional | - | Sportivo Luqueño | 1:0 | ||||
| 13. Round | 26/04/2021 | Libertad | - | Club Nacional | 1:1 | ||||
| 14. Round | 30/04/2021 | Club Nacional | - | Guaireña FC | 1:3 |  |
|||
| 15. Round | 09/05/2021 | Cerro Porteño | - | Club Nacional | 2:2 |  |
|
||
| 16. Round | 17/05/2021 | Club Nacional | - | Club Olimpia | 2:1 | ||||
| 17. Round | 24/05/2021 | Club Nacional | - | River Plate | 0:1 | ||||
| 18. Round | 31/05/2021 | 12 de Octubre de Itauguá | - | Club Nacional | 2:2 |  |
Paraguay