1. Round | 06/02/2022 | Guaireña FC | - | Guaraní | 0:0 | ||||
2. Round | 13/02/2022 | Guaraní | - | Sol de América | 0:1 | ||||
4. Round | 26/02/2022 | Guaraní | - | Resistencia SC | 3:3 | ||||
6. Round | 12/03/2022 | Guaraní | - | General Caballero DJLM | 3:1 | ||||
8. Round | 04/04/2022 | Guaraní | - | Tacuary | 1:2 |