| 1. Round | 23/07/2017 | Sportivo Trinidense | - | Guaraní | 1:3 | ||||
| 3. Round | 05/08/2017 | Libertad | - | Guaraní | 0:0 | ||||
| 16. Round | 29/10/2017 | Guaraní | - | Club Olimpia | 3:0 | ||||
| 17. Round | 05/11/2017 | Club Nacional | - | Guaraní | 0:4 | ||||
| 18. Round | 12/11/2017 | Guaraní | - | Club Rubio Ñu | 0:1 | ||||
| 21. Round | 02/12/2017 | Guaraní | - | Cerro Porteño | 2:1 | ||||
| 22. Round | 07/12/2017 | General Díaz | - | Guaraní | 5:2 |  |
Paraguay
Argentina