| 15. Round | 06/12/1980 | Feyenoord | - | AFC Ajax | 4:2 | ||||
| 16. Round | 13/12/1980 | AFC Ajax | - | Willem II | 1:1 | ||||
| 22. Round | 06/03/1981 | PSV Eindhoven | - | AFC Ajax | 3:1 |  |
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| 23. Round | 14/03/1981 | AFC Ajax | - | SBV Excelsior | 7:2 | ||||
| 24. Round | 28/03/1981 | FC Groningen | - | AFC Ajax | 0:1 | ||||
| 17. Round | 31/03/1981 | FC Utrecht | - | AFC Ajax | 1:2 | ||||
| 25. Round | 04/04/1981 | AFC Ajax | - | FC Den Haag | 2:0 | ||||
| 26. Round | 10/04/1981 | AZ '67 Alkmaar | - | AFC Ajax | 0:1 | ||||
| 27. Round | 17/04/1981 | AFC Ajax | - | PEC Zwolle | 2:1 | ||||
| 28. Round | 24/04/1981 | SC NEC | - | AFC Ajax | 0:0 | ||||
| 29. Round | 02/05/1981 | AFC Ajax | - | Sparta Rotterdam | 2:1 | ||||
| 30. Round | 09/05/1981 | AFC Ajax | - | MVV | 6:1 | ||||
| 21. Round | 11/05/1981 | AFC Ajax | - | NAC Breda | 4:1 | ||||
| 31. Round | 16/05/1981 | FC Twente | - | AFC Ajax | 3:0 | ||||
| 32. Round | 23/05/1981 | AFC Ajax | - | Feyenoord | 4:1 | ||||
| 33. Round | 29/05/1981 | Willem II | - | AFC Ajax | 1:3 | ||||
| 34. Round | 05/06/1981 | AFC Ajax | - | FC Utrecht | 1:0 |
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