| 1. Round | 02/07/2022 | Deportivo Guadalajara [U18] | - | FC Juárez [U18] | 1:0 | ||||
| 3. Round | 05/07/2022 | Santos Laguna [U18] | - | Deportivo Guadalajara [U18] | 3:1 |  |
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| 2. Round | 09/07/2022 | Deportivo Guadalajara [U18] | - | Atlético San Luis [U18] | 3:1 | |
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| 4. Round | 20/07/2022 | Deportivo Guadalajara [U18] | - | Club León [U18] | 2:2 | |
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| 5. Round | 27/07/2022 | Gallos Blancos [U18] | - | Deportivo Guadalajara [U18] | 0:1 |  |
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| 6. Round | 30/07/2022 | Deportivo Guadalajara [U18] | - | CF Pachuca [U18] | 0:1 | ||||
| 7. Round | 05/08/2022 | Mazatlán FC [U18] | - | Deportivo Guadalajara [U18] | 2:2 | ||||
| 8. Round | 13/08/2022 | Deportivo Guadalajara [U18] | - | Atlas Guadalajara [U18] | 0:1 | ||||
| 13. Round | 07/09/2022 | Club Tijuana [U18] | - | Deportivo Guadalajara [U18] | 1:0 | ||||
| 14. Round | 10/09/2022 | Deportivo Guadalajara [U18] | - | Puebla FC [U18] | 1:1 | |
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| 9. Round | 13/09/2022 | Deportivo Guadalajara [U18] | - | UANL Tigres [U18] | 2:2 | ||||
| 15. Round | 17/09/2022 | CF América [U18] | - | Deportivo Guadalajara [U18] | 0:3 | |
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| 17. Round | 01/10/2022 | Cruz Azul [U18] | - | Deportivo Guadalajara [U18] | 0:4 |
Mexico