| 1. Round | 19/08/2024 | Defensor Sporting | - | Rampla Juniors | 1:2 | ||||
| 2. Round | 07/09/2024 | CA Cerro | - | Defensor Sporting | 1:1 | ||||
| 6. Round | 05/10/2024 | Danubio | - | Defensor Sporting | 1:1 |  |
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| 7. Round | 12/10/2024 | Defensor Sporting | - | Boston River | 1:2 | ||||
| 9. Round | 21/10/2024 | Defensor Sporting | - | Liverpool | 2:1 | ||||
| 12. Round | 14/11/2024 | Defensor Sporting | - | Progreso | 3:0 | ||||
| 13. Round | 17/11/2024 | Peñarol | - | Defensor Sporting | 2:0 | |
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| 14. Round | 27/11/2024 | Cerro Largo | - | Defensor Sporting | 3:0 |
Mexico