| 1. Round | 08/08/2021 | Union Titus Pétange | - | UNA Strassen | 1:2 |  |
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| 3. Round | 23/08/2021 | Union Titus Pétange | - | FC Rodange 91 | 3:0 | ||||
| 4. Round | 29/08/2021 | RM Hamm Benfica | - | Union Titus Pétange | 0:3 | ||||
| 12. Round | 21/11/2021 | Union Titus Pétange | - | Etzella Ettelbruck | 4:1 |  |
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| 13. Round | 28/11/2021 | FC Differdange 03 | - | Union Titus Pétange | 4:0 | ||||
| 14. Round | 05/12/2021 | Union Titus Pétange | - | Victoria Rosport | 0:3 | |
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| 17. Round | 12/02/2022 | FC Rodange 91 | - | Union Titus Pétange | 0:4 | |
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| 16. Round | 16/02/2022 | Union Titus Pétange | - | Swift Hesperange | 0:3 | ||||
| 18. Round | 20/02/2022 | Union Titus Pétange | - | RM Hamm Benfica | 3:1 | |
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| 19. Round | 27/02/2022 | FC Wiltz 71 | - | Union Titus Pétange | 3:2 |  |
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| 20. Round | 06/03/2022 | Union Titus Pétange | - | F91 Dudelange | 0:1 | |
Luxembourg