| 1. Round | 11/07/2022 | Club Necaxa [Women] | - | Club León [Women] | 0:2 | ||||
| 3. Round | 24/07/2022 | Club León [Women] | - | Cruz Azul [Women] | 0:2 | ||||
| 5. Round | 02/08/2022 | Santos Laguna [Women] | - | Club León [Women] | 1:2 |  |
|||
| 6. Round | 09/08/2022 | Club León [Women] | - | CF América [Women] | 2:2 | ||||
| 9. Round | 25/08/2022 | Club León [Women] | - | Mazatlán FC [Women] | 3:1 | ||||
| 14. Round | 26/09/2022 | Club León [Women] | - | Deportivo Guadalajara [Women] | 0:1 | ||||
| 15. Round | 01/10/2022 | Pumas UNAM [Women] | - | Club León [Women] | 4:0 | ||||
| 16. Round | 17/10/2022 | Club León [Women] | - | UANL Tigres [Women] | 2:0 | ||||
| 13. Round | 20/10/2022 | Puebla FC [Women] | - | Club León [Women] | 0:3 | ||||
| 17. Round | 24/10/2022 | Club León [Women] | - | Deportivo Toluca [Women] | 1:2 | |
Mexico