| 18. Round | 13/02/2022 | APS Zakynthos | - | GS Kallithea | 1:2 |  |
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| 19. Round | 16/02/2022 | AO Egaleo | - | APS Zakynthos | 2:1 | ||||
| 20. Round | 20/02/2022 | APS Zakynthos | - | Irodotos | 1:0 | ||||
| 22. Round | 06/03/2022 | APS Zakynthos | - | AS Rhodos | 0:3 dec. | ||||
| 23. Round | 09/03/2022 | AO Episkopi | - | APS Zakynthos | 1:0 | ||||
| 24. Round | 13/03/2022 | APS Zakynthos | - | AE Kifisias | 1:1 | |
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| 17. Round | 16/03/2022 | APS Zakynthos | - | OFI Ierapetra | 1:1 | ||||
| 30. Round | 10/04/2022 | APS Zakynthos | - | Asteras Vlachioti | 1:1 | |
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| 32. Round | 17/04/2022 | APS Zakynthos | - | PAE Chania | 3:1 | ||||
| 34. Round | 01/05/2022 | OFI Ierapetra | - | APS Zakynthos | 5:1 |  |
Morocco