| 3. Round | 02/10/2021 | Escorpiones | - | Inter de Querétaro | 1:1 | ||||
| 6. Round | 16/10/2021 | Inter de Querétaro | - | Inter Playa | 0:0 |  |
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| 7. Round | 23/10/2021 | Inter de Querétaro | - | Montañeses FC | 0:0 | ||||
| 9. Round | 06/11/2021 | Inter de Querétaro | - | Sporting Canamy | 1:0 | |
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| 13. Round | 27/11/2021 | Inter de Querétaro | - | Deportivo Dongu | 3:0 |
Colombia