| 2. Round | 15/01/2022 | Club Tijuana [U20] | - | Club León [U20] | 1:2 | ||||
| 3. Round | 22/01/2022 | Club León [U20] | - | CF Pachuca [U20] | 4:3 | ||||
| 4. Round | 07/02/2022 | Club León [U20] | - | Cruz Azul [U20] | 2:1 | ||||
| 5. Round | 13/02/2022 | Pumas UNAM [U20] | - | Club León [U20] | 2:1 | ||||
| 12. Round | 03/04/2022 | Club León [U20] | - | Gallos Blancos [U20] | 2:1 | ||||
| 16. Round | 24/04/2022 | Santos Laguna [U20] | - | Club León [U20] | 0:3 |
Mexico