| 2. Round | 23/01/2022 | Isidro Metapán | - | AD Chalatenango | 2:1 |  |
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| 3. Round | 27/01/2022 | Luis Ángel Firpo | - | Isidro Metapán | 0:0 | ||||
| 4. Round | 30/01/2022 | Isidro Metapán | - | Platense Zacatecoluca | 0:0 | ||||
| 5. Round | 06/02/2022 | Once Municipal | - | Isidro Metapán | 0:0 | |
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| 8. Round | 20/02/2022 | Isidro Metapán | - | FAS | 1:1 | ||||
| 9. Round | 24/02/2022 | Santa Tecla FC | - | Isidro Metapán | 1:0 | ||||
| 10. Round | 27/02/2022 | Isidro Metapán | - | Municipal Limeño | 2:0 | |
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| 11. Round | 05/03/2022 | Atlético Marte | - | Isidro Metapán | 0:1 | |
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| 12. Round | 13/03/2022 | Isidro Metapán | - | Alianza | 0:0 | |
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| 14. Round | 24/03/2022 | Isidro Metapán | - | Luis Ángel Firpo | 1:1 | |
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| 15. Round | 03/04/2022 | Platense Zacatecoluca | - | Isidro Metapán | 2:1 |
Colombia