| 1. Round | 07/08/2021 | EA Guingamp B | - | FC Rouen 1899 | 0:0 | ||||
| 7. Round | 18/09/2021 | EA Guingamp B | - | Blois Foot 41 | 2:3 |  |
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| 8. Round | 25/09/2021 | FC Lorient B | - | EA Guingamp B | 3:0 | ||||
| 11. Round | 06/11/2021 | C'Chartres Football | - | EA Guingamp B | 1:2 | ||||
| 12. Round | 20/11/2021 | EA Guingamp B | - | Châteaubriant Voltigeurs | 2:3 | |
France