| 1. Round | 30/07/2017 | KV Mechelen | - | Standard Liège | 1:1 | ||||
| 2. Round | 05/08/2017 | Waasland-Beveren | - | KV Mechelen | 2:2 | ||||
| 3. Round | 12/08/2017 | KV Mechelen | - | KAA Gent | 1:1 | ||||
| 4. Round | 19/08/2017 | KV Mechelen | - | Royal Antwerp FC | 1:2 | ||||
| 5. Round | 26/08/2017 | KRC Genk | - | KV Mechelen | 1:0 | ||||
| 6. Round | 10/09/2017 | KV Mechelen | - | KV Oostende | 1:1 | ||||
| 7. Round | 15/09/2017 | Club Brugge KV | - | KV Mechelen | 2:0 | ||||
| 8. Round | 23/09/2017 | KV Mechelen | - | Sint-Truidense VV | 2:0 | ||||
| 9. Round | 30/09/2017 | Royal Excel Mouscron | - | KV Mechelen | 2:2 | ||||
| 10. Round | 13/10/2017 | KV Mechelen | - | RSC Anderlecht | 3:4 | ||||
| 11. Round | 21/10/2017 | KAS Eupen | - | KV Mechelen | 4:1 |  |
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| 12. Round | 24/10/2017 | KV Mechelen | - | Sporting Lokeren | 0:2 | ||||
| 13. Round | 28/10/2017 | SV Zulte Waregem | - | KV Mechelen | 2:1 | ||||
| 14. Round | 04/11/2017 | KV Mechelen | - | KV Kortrijk | 2:0 | ||||
| 15. Round | 17/11/2017 | Sporting Charleroi | - | KV Mechelen | 2:0 |
France