| 1. Round | 06/02/2016 | Sud América | - | Defensor Sporting | 2:0 | ||||
| 2. Round | 14/02/2016 | Defensor Sporting | - | Racing | 1:3 | ||||
| 3. Round | 21/02/2016 | Peñarol | - | Defensor Sporting | 5:1 | ||||
| 4. Round | 28/02/2016 | Defensor Sporting | - | Danubio | 3:2 | ||||
| 5. Round | 06/03/2016 | Rentistas | - | Defensor Sporting | 0:1 | ||||
| 6. Round | 20/03/2016 | Defensor Sporting | - | Liverpool | 1:2 | ||||
| 7. Round | 02/04/2016 | Villa Teresa | - | Defensor Sporting | 2:2 |  |
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| 8. Round | 10/04/2016 | Defensor Sporting | - | Nacional | 2:4 | ||||
| 9. Round | 23/04/2016 | Montevideo Wanderers | - | Defensor Sporting | 0:0 | ||||
| 10. Round | 30/04/2016 | Defensor Sporting | - | Plaza Colonia | 1:1 | ||||
| 11. Round | 08/05/2016 | Juventud de Las Piedras | - | Defensor Sporting | 2:1 | ||||
| 12. Round | 14/05/2016 | Defensor Sporting | - | CA Cerro | 1:0 | ||||
| 13. Round | 22/05/2016 | El Tanque Sisley | - | Defensor Sporting | 5:6 | ||||
| 14. Round | 29/05/2016 | River Plate | - | Defensor Sporting | 1:2 | ||||
| 15. Round | 05/06/2016 | Defensor Sporting | - | Fénix | 1:0 |
Uruguay