| 2. Round | 06/08/2022 | Nacional | - | Rentistas | 3:0 |  |
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| 3. Round | 14/08/2022 | Liverpool | - | Nacional | 0:1 | |
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| 6. Round | 20/08/2022 | Nacional | - | Montevideo Wanderers | 2:0 | ||||
| 9. Round | 17/09/2022 | River Plate | - | Nacional | 1:1 | ||||
| 10. Round | 25/09/2022 | Nacional | - | Cerro Largo | 1:1 | ||||
| 11. Round | 01/10/2022 | Fénix | - | Nacional | 1:1 | |
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| 12. Round | 08/10/2022 | Nacional | - | Defensor Sporting | 1:1 | |
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| 13. Round | 13/10/2022 | Albion | - | Nacional | 0:1 | ||||
| 15. Round | 23/10/2022 | Nacional | - | Danubio | 2:0 |
Uruguay