| Group 2 | 18/10/2020 | Atlético Marte | - | Santa Tecla FC | 1:1 | ||||
| Group 2 | 25/10/2020 | Santa Tecla FC | - | AD Chalatenango | 1:1 |  |
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| Group B | 06/12/2020 | FAS | - | Santa Tecla FC | 1:1 |  |
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| Group B | 19/12/2020 | Santa Tecla FC | - | Once Municipal | 1:1 | |
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| Group B | 24/12/2020 | Santa Tecla FC | - | AD Chalatenango | 3:1 | ||||
| Group B | 27/12/2020 | Municipal Limeño | - | Santa Tecla FC | 3:0 | ||||
| Group B | 03/01/2021 | Santa Tecla FC | - | FAS | 0:2 | ||||
| Group B | 09/01/2021 | Luis Ángel Firpo | - | Santa Tecla FC | 0:3 |  |
Colombia