| 1. Round | 16/01/2022 | Luis Ángel Firpo | - | Municipal Limeño | 1:0 |  |
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| 2. Round | 23/01/2022 | Municipal Limeño | - | Platense Zacatecoluca | 2:1 | ||||
| 3. Round | 26/01/2022 | Once Municipal | - | Municipal Limeño | 3:2 | ||||
| 4. Round | 30/01/2022 | Municipal Limeño | - | CD Águila | 0:3 | |
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| 5. Round | 04/02/2022 | Jocoro FC | - | Municipal Limeño | 3:0 | |
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| 6. Round | 09/02/2022 | Municipal Limeño | - | FAS | 1:1 |  |
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| 7. Round | 13/02/2022 | Santa Tecla FC | - | Municipal Limeño | 1:1 | |
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| 8. Round | 20/02/2022 | Municipal Limeño | - | Alianza | 0:0 | |
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| 10. Round | 27/02/2022 | Isidro Metapán | - | Municipal Limeño | 2:0 | |
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| 11. Round | 06/03/2022 | Municipal Limeño | - | AD Chalatenango | 0:1 | ||||
| 12. Round | 13/03/2022 | Municipal Limeño | - | Luis Ángel Firpo | 3:2 | |
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| 13. Round | 20/03/2022 | Platense Zacatecoluca | - | Municipal Limeño | 1:0 | |
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| 14. Round | 25/03/2022 | Municipal Limeño | - | Once Municipal | 0:0 | ||||
| 15. Round | 03/04/2022 | CD Águila | - | Municipal Limeño | 1:0 |  |
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| 18. Round | 17/04/2022 | Municipal Limeño | - | Santa Tecla FC | 2:0 | ||||
| 19. Round | 24/04/2022 | Alianza | - | Municipal Limeño | 4:0 | |
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| 20. Round | 27/04/2022 | Atlético Marte | - | Municipal Limeño | 0:1 | |
Colombia