| 6. Round | 27/02/2010 | Cerro Largo | - | Atenas | 0:2 | ||||
| 7. Round | 07/03/2010 | Peñarol | - | Cerro Largo | 5:0 | ||||
| 8. Round | 13/03/2010 | Cerro Largo | - | Defensor Sporting | 1:3 |  |
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| 10. Round | 27/03/2010 | Cerro Largo | - | Rampla Juniors | 1:1 |  |
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| 11. Round | 04/04/2010 | Montevideo Wanderers | - | Cerro Largo | 7:1 | ||||
| 12. Round | 10/04/2010 | Cerro Largo | - | River Plate | 2:2 | ||||
| 14. Round | 25/04/2010 | Liverpool | - | Cerro Largo | 3:0 | ||||
| 15. Round | 02/05/2010 | Cerro Largo | - | Tacuarembó | 1:2 | |
Colombia