| 1. Round | 02/08/2009 | Feyenoord | - | NEC Nijmegen | 2:0 | ||||
| 2. Round | 07/08/2009 | NEC Nijmegen | - | sc Heerenveen | 4:1 |  |
|||
| 3. Round | 16/08/2009 | Roda JC Kerkrade | - | NEC Nijmegen | 1:0 | ||||
| 5. Round | 29/08/2009 | NEC Nijmegen | - | VVV-Venlo | 1:1 | ||||
| 6. Round | 13/09/2009 | Vitesse | - | NEC Nijmegen | 2:2 | ||||
| 7. Round | 19/09/2009 | AZ Alkmaar | - | NEC Nijmegen | 0:1 | ||||
| 8. Round | 27/09/2009 | NEC Nijmegen | - | Heracles Almelo | 0:2 | ||||
| 4. Round | 30/09/2009 | NEC Nijmegen | - | FC Utrecht | 1:1 | ||||
| 9. Round | 03/10/2009 | Willem II | - | NEC Nijmegen | 1:1 | ||||
| 10. Round | 18/10/2009 | NEC Nijmegen | - | ADO Den Haag | 1:1 | ||||
| 11. Round | 25/10/2009 | NEC Nijmegen | - | PSV Eindhoven | 0:4 |  |
|||
| 12. Round | 01/11/2009 | Sparta Rotterdam | - | NEC Nijmegen | 2:0 | |
|||
| 13. Round | 07/11/2009 | NEC Nijmegen | - | RKC Waalwijk | 0:1 | |
|||
| 14. Round | 21/11/2009 | NAC Breda | - | NEC Nijmegen | 3:3 | ||||
| 15. Round | 29/11/2009 | FC Groningen | - | NEC Nijmegen | 2:2 | |
|||
| 16. Round | 06/12/2009 | NEC Nijmegen | - | FC Twente | 3:4 | ||||
| 17. Round | 11/12/2009 | AFC Ajax | - | NEC Nijmegen | 3:0 |
Netherlands