| 3. Round | 21/08/2010 | sc Heerenveen | - | NAC Breda | 3:1 | ||||
| 4. Round | 28/08/2010 | NEC Nijmegen | - | sc Heerenveen | 2:2 | ||||
| 5. Round | 11/09/2010 | sc Heerenveen | - | Vitesse | 2:1 | ||||
| 6. Round | 17/09/2010 | De Graafschap | - | sc Heerenveen | 3:2 | ||||
| 7. Round | 25/09/2010 | sc Heerenveen | - | Roda JC Kerkrade | 2:2 | ||||
| 15. Round | 21/11/2010 | sc Heerenveen | - | Willem II | 5:0 |
Netherlands