| 1. Round | 18/09/2008 | NEC Nijmegen | - | Dinamo Bucureşti | 1:0 | ||||
| 1. Round | 02/10/2008 | Dinamo Bucureşti | - | NEC Nijmegen | 0:0 |  |
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| Group D | 23/10/2008 | Dinamo Zagreb | - | NEC Nijmegen | 3:2 | ||||
| Group D | 27/11/2008 | NEC Nijmegen | - | Tottenham Hotspur | 0:1 | ||||
| Group D | 03/12/2008 | Spartak Moskva | - | NEC Nijmegen | 1:2 | ||||
| Group D | 18/12/2008 | NEC Nijmegen | - | Udinese Calcio | 2:0 | ||||
| 3. Round | 18/02/2009 | NEC Nijmegen | - | Hamburger SV | 0:3 | ||||
| 3. Round | 26/02/2009 | Hamburger SV | - | NEC Nijmegen | 1:0 |
Netherlands