| 1. Round | 11/08/2019 | Lille OSC | - | FC Nantes | 2:1 | ||||
| 2. Round | 17/08/2019 | Amiens SC | - | Lille OSC | 1:0 | ||||
| 3. Round | 28/08/2019 | Lille OSC | - | AS Saint-Étienne | 3:0 | ||||
| 4. Round | 01/09/2019 | Stade de Reims | - | Lille OSC | 2:0 |  |
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| 6. Round | 22/09/2019 | Stade Rennais | - | Lille OSC | 1:1 | ||||
| 7. Round | 25/09/2019 | Lille OSC | - | RC Strasbourg | 2:0 | ||||
| 8. Round | 28/09/2019 | OGC Nice | - | Lille OSC | 1:1 | ||||
| 9. Round | 06/10/2019 | Lille OSC | - | Nîmes Olympique | 2:2 | ||||
| 10. Round | 19/10/2019 | Toulouse FC | - | Lille OSC | 2:1 | ||||
| 11. Round | 26/10/2019 | Lille OSC | - | Girondins Bordeaux | 3:0 |  |
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| 12. Round | 02/11/2019 | Olympique Marseille | - | Lille OSC | 2:1 | ||||
| 13. Round | 09/11/2019 | Lille OSC | - | FC Metz | 0:0 | ||||
| 14. Round | 22/11/2019 | Paris Saint-Germain | - | Lille OSC | 2:0 | ||||
| 15. Round | 30/11/2019 | Lille OSC | - | Dijon FCO | 1:0 | ||||
| 16. Round | 03/12/2019 | Olympique Lyonnais | - | Lille OSC | 0:1 | ||||
| 17. Round | 06/12/2019 | Lille OSC | - | Stade Brestois 29 | 1:0 | ||||
| 18. Round | 13/12/2019 | Lille OSC | - | Montpellier HSC | 2:1 | ||||
| 19. Round | 21/12/2019 | AS Monaco | - | Lille OSC | 5:1 |
Turkey