| 4. Round | 15/08/2021 | Anzhi Makhachkala | - | Dinamo Stavropol | 2:1 | ||||
| 18. Round | 12/11/2021 | FK Tuapse | - | Anzhi Makhachkala | 1:1 | ||||
| 19. Round | 19/11/2021 | Anzhi Makhachkala | - | FK SKA Rostov | 0:0 | ||||
| 20. Round | 06/03/2022 | Dinamo Stavropol | - | Anzhi Makhachkala | 2:3 |  |
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| 21. Round | 13/03/2022 | Anzhi Makhachkala | - | Chernomorets Novorossisk | 1:1 | |
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| 22. Round | 21/03/2022 | FK Yessentuki | - | Anzhi Makhachkala | 0:0 | ||||
| 23. Round | 28/03/2022 | Anzhi Makhachkala | - | FK Biolog Novokubansk | 1:1 | ||||
| 24. Round | 03/04/2022 | Anzhi Makhachkala | - | FK Legion Dynamo Makhachkala | 2:0 |  |
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| 25. Round | 10/04/2022 | Anzhi Makhachkala | - | FK Mashuk KMV | 1:1 | |
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| 26. Round | 17/04/2022 | Spartak Nalchik | - | Anzhi Makhachkala | 3:1 | ||||
| 27. Round | 23/04/2022 | Anzhi Makhachkala | - | FK Chayka | 3:6 | ||||
| 29. Round | 06/05/2022 | FK Druzhba | - | Anzhi Makhachkala | 2:2 | ||||
| 30. Round | 11/05/2022 | Anzhi Makhachkala | - | Alania-2 Vladikavkaz | 1:0 | ||||
| 32. Round | 23/05/2022 | Anzhi Makhachkala | - | Forte Taganrog | 2:2 | ||||
| 33. Round | 29/05/2022 | FK Dinamo Makhachkala | - | Anzhi Makhachkala | 2:0 | ||||
| 34. Round | 05/06/2022 | Rotor-2 Volgograd | - | Anzhi Makhachkala | 0:4 |
Russia