| 1. Round | 18/01/2021 | Plaza Colonia | - | Liverpool | 0:0 | ||||
| 2. Round | 21/01/2021 | Plaza Colonia | - | Progreso | 0:1 | ||||
| 3. Round | 29/01/2021 | Fénix | - | Plaza Colonia | 3:3 | ||||
| 4. Round | 04/02/2021 | Plaza Colonia | - | CA Cerro | 2:1 | ||||
| 5. Round | 07/02/2021 | Defensor Sporting | - | Plaza Colonia | 3:2 |  |
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| 8. Round | 19/02/2021 | Plaza Colonia | - | Boston River | 3:0 | ||||
| 10. Round | 01/03/2021 | Plaza Colonia | - | Rentistas | 5:0 | ||||
| 12. Round | 12/03/2021 | Plaza Colonia | - | Montevideo Wanderers | 3:0 | ||||
| 13. Round | 20/03/2021 | Peñarol | - | Plaza Colonia | 1:3 | ||||
| 14. Round | 26/03/2021 | Plaza Colonia | - | River Plate | 1:0 | ||||
| 15. Round | 29/03/2021 | Montevideo City Torque | - | Plaza Colonia | 2:0 |
Uruguay