| 1. Round | 06/02/2022 | Boston River | - | Plaza Colonia | 0:0 | ||||
| 2. Round | 12/02/2022 | Plaza Colonia | - | River Plate | 0:1 | ||||
| 3. Round | 18/02/2022 | Cerro Largo | - | Plaza Colonia | 0:5 |  |
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| 4. Round | 25/02/2022 | Plaza Colonia | - | Fénix | 1:1 | |
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| 5. Round | 12/03/2022 | Defensor Sporting | - | Plaza Colonia | 0:0 | ||||
| 6. Round | 19/03/2022 | Plaza Colonia | - | Albion | 1:1 |
Uruguay